Latest Research


How Much HIV is Alive? The Challenge of Measuring Replication Competent HIV for HIV Cure Research
EBioMedicine
31 July 2015

Innate immune activity correlates with CD4 T cell-associated HIV-1 DNA decline during latency-reversing treatment with panobinostat
Journal of Virology
29 July 2015

Bone Marrow Gene Therapy for HIV/AIDS
Viruses
17 July 2015

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency
American Society for Microbiology
7 July 2015

HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days – Implications for HIV Remission
PLOS Pathogens
2 July 2015

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals
EBioMedicine
30 June 2015

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection
Nature Communications
25 June 2015

Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy
Clinical Infectious Diseases
10 June 2015

HIV-specific Immunity Derived from Chimeric Antigen Receptor-engineered Stem Cells
Molecular Therapy
8 June 2015

Can HIV-1-specific ADCC assist the clearance of reactivated latently infected cells?
Frontiers in Immunology
27 May 2015

Stakeholder Engagement in HIV Cure Research: Lessons Learned from other HIV Interventions and the Way Forward
AIDS Patient Care and STDs
18 May 2015

Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission
Journal of Antimicrobial Chemotherapy
21 April 2015

Precise Quantification of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
The Journal of Infectious Diseases
15 April 2015

The Remarkable Stability of the Latent Reservoir for HIV-1 in Resting Memory CD4+ T Cells
The Journal of Infectious Diseases
15 April 2015

Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations
The Journal of Clinical Investigation
30 March 2015

Towards an HIV-1 cure: measuring the latent reservoir
Trends in Microbiology
4 March 2015

Recruitment and ethical considerations in HIV cure trial requiring treatment interruption
Journal of Virus Eradication
January 2015

How to Cure AIDS: Feeding the Elephant
AIDS Research and Human Retroviruses
12 January 2015

The business case for cell and gene therapies
Nature Biotechnology
9 December 2014

Advancing the HIV Cure agenda: the next 5 years
Current Opinion in Infectious Diseases
6 December 2014

2014 Syposium Report: Towards an HIV Cure
4 November 2014

Words Matter: Discussing Research Towards an HIV Cure in Research and Clinical Contexts
Journal of Acquired Immune Deficiency Syndromes
1 November 2014

Q&A Françoise Barré-Sinoussi: HIV Adversary
Nature
16 October 2014

Influence of Age at Virologic Control on Peripheral Blood Human Immunodeficiency Virus Reservoir Size and Serostatus in Perinatally Infected Adolescents
JAMA Pediatrics
6 October 2014

Targeting NF-ĸB signaling with protein kinase C agonists as an emerging strategy for combating HIV latency
AIDS Research and Human Retroviruses
6 October 2014

No cure of HIV infection in a child despite early treatment and apparent viral clearance
The Lancet
4 October 2014

Finding a cure for human immunodeficiency virus-1 infection
Infectious disease clinics of North America
2 October 2014

Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load
European Journal of Immunology
15 September 2014

HIV-1 DNA predicts disease progression and post-treatment virological control
eLIFE
12 September 2014

Selective HDAC inhibition for the disruption of latent HIV-1 infection
PLoS One
19 August 2014

The maturation of antibody technology for the HIV epidemic 
Immunology & Cell Biology
August 2014

Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1
Proceedings of the National Academy of Sciences of the USA
5 August 2014

HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research
Journal of NeuroVirology
25 July 2014

Immunologic strategies for HIV-1 remission and eradication
Science
11 July 2014

Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1
Journal of Allergy and Clinical Immunology
July 2014

Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition and decay kinetics of the reservoir of HIV-1-infected CD4 T cells
Journal of Virology
25 June 2014

Listing: Research Toward a Cure Trials
Treatment Action Group
22 May 2014

Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?
Philosophical Transactions of the Royal Society: Biological Sciences
12 May 2014

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
Nature
2 March 2014

HIV Cure Research: Expanding the Ethical Considerations
Annals of Internal Medicine
13 August 2013

Interleukin-7 promotes HIV persistence during antiretroviral therapy
Blood
23 May 2013

Understanding Therapeutic Vaccination
The Bulletin on AIDS Vaccine Research
March 2013

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study
PLOS Pathogens
14 March 2013

Long-term reduction in peripheral blood HIV Type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation
The Journal of Infectious Diseases
4 March 2013

Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long anti-sense to HIV
Blood
20 December 2012

The Cure Conundrum
Nature Medicine
7 September 2012

Dynamics of the resting CD4(+) T-cell latent  HIV reservoir in infants initiating HAART less than 6 months of age
AIDS
31 July 2012

Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF-κB Activation
Journal of Virology
20 June 2012

Effects of rhIL-7 on T Cell Recovery and Thymic Output in HIV-infected Patients receiving antiretroviral therapy: results of a Phase I/IIa Randomized, Placebo Controlled, Multicenter Study 
Clinical Infectious Diseases
1 May 2012

Do opioids activate latent HIV-1 by down-regulating anti-HIV microRNAs?
Journal of NeuroImmune Pharmacology
17 April 2012

Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells
Clinical Infectious Diseases
22 March 2012

HIV Reservoirs: Pathogenesis and Obstacles to Viral Eradication and Cure
AIDS
21 March 2012

Controversies in HIV cure research
JIAS
16 March 2012

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
Nature Immunology
12 February 2012

Achieving a cure for HIV infection: do we have reasons to be optimistic?
Journal of Antimicrobial Chemotherapy
31 January 2012

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study
HIV Medicine
26 January 2012

A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs
PLOS One
24 January 2012