Nationality: South African
Institution: Stellenbosch University
Country of work: South Africa
What is your motivation for engaging in HIV cure and remission research?
As a paediatrician involved in clinical work and research, I am exposed to the scientific aspects of HIV research and the clinical application and positive outcomes in patient management and care. It is this holistic understanding that motivates me to become involved and engaged in HIV cure and remission research. I am particularly keen to deepen my knowledge and understanding of the virologic aspects of HIV reservoirs and the immunologic characteristics of HIV+ children and adolescents. Clinically, I am interested in the neurodevelopmental outcomes of HIV exposed, uninfected and HIV+ children, particularly those who participate in remission and cure research.
What is your current area of research?
My areas of research include trials involving broadly neutralizing monoclonal antibodies in HIV+ and HIV exposed uninfected children and pharmacokinetic, safety and efficacy trials of novel antiretrovirals and treatment strategies. The PK studies also involve infants and children with TB/HIV coinfection, investigating drug interactions. Another area of research is a prospective look at the neurodevelopmental outcomes of HIV exposed, uninfected infants with a neuroimaging component using MRI. I am involved in establishing a long-term cohort and a biorepository of children involved in early and very early ART clinical trials with an interest in future cure and remission research.