Research-for-Cure Academy

Livia Ramos Goes

Nationality: Brazilian
Institution: Instituto Nacional de Cancer
Country of work: Brazil

What is your motivation for engaging in HIV cure and remission research?

More than 30 years of AIDS research rendered highly effective antiretroviral therapy to control HIV, yet drugs alone are not curative, and therapy interruption leads to viral rebound. Efforts to elucidate viral reservoirs and ultimately cure HIV are of tantamount importance. My motivation for engaging in this research stems from growing research to find new models and strategies to address HIV cure and remission. Such scenarios motivate me and make me passionate about finding strategies to improve the lifespan of people living with HIV and, ultimately, achieve the HIV cure.

What is your current area of research?

As a graduate student I investigated the role of integrin alpha4 beta7 in the early stages of HIV infection. Later in my postdoctoral training I began looking at cell signaling patterns in lymphocytes, mainly CD4 T cells and aberrations and abnormalities in T cell signaling that result from HIV-1 infection. My studies also aim to elucidate aspects involving the rapid seeding of HIV in the gut tissues and particularly the establishment of reservoirs. More recently I have engaged in a project aiming to evaluate the effect of the gut microbiome in HIV evolution before and during ART.